Affinity and kinetics
Study ligand-receptor interactions in real-time to learn about the affinity and kinetics
Knowledge about the affinity and kinetics of interactions is of great value when ranking drug leads, developing radiotracers or investigating a receptor system. Fit curves with the model that best describes the biology – most likely found in our large library of models.
- The affinity of the interaction (KD)
- Kinetic rate constants (ka and kd)
- The ligand residence time (t1/2)
- Possible deviations from a one-to-one binding mode
- The concentration required to saturate targets
Real-time characterization of antibody binding to receptors on living immune cells.
Bondza S, Foy E, Brooks J, Andersson K, Robinson J, Richalet P, Buijs J.
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Development of Human Monoclonal Antibody for Claudin-3 Overexpressing Carcinoma Targeting.
Yang H, Park H,Jin Lee Y, Young Choi J, Kim TE, Rajasekaran N, Lee S, Song K, Hong S, Choi J-S, Shim H, Kim Y-D, Hwang S, Choi Y-L, Kee Shin Y.
Biomolecules. 2020. 10(1): 51.