Products

We provide you with knowledge about your interaction in a living system

Imagine that you are developing a drug in a major pharma company and you have a few candidates to choose from, to proceed with animal experiments and hopefully clinical trials. But which is the best candidate? What information would you benefit from in your selection?

Or imagine that you are working in a preclinical research group trying to understand a receptor system. With what strength and rate do the ligands bind? And how about secondary targets, clustering, internalization and recycling?

In these critical situations LigandTracer can be the solution. It enables a real-time interaction analysis on live cells, thus filling in the gap between purified systems and in vivo environments, and provides information about interaction rates, the affinity, binding mechanism and the impact of cellular processes. Understanding a system in detail early in the process reduces the risk of unexpected and critical results when moving on to animals or humans – experiments that are both costly and time-consuming.

LigandTracer Green open

LigandTracer is not just an instrument – it is a COMPLETE package

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Instrument
Measure interactions in real time on live cells with the LigandTracer instrument. The intuitive control software lets you set up a run in no time. A large number of applications are available.
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TraceDrawer
The software transfers relevant information from your run and lets you characterize the interaction with a few button-clicks. Multiple tools and models are available for a more thorough analysis.
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Training
Use the interactive self-learning software to quickly get started, or attend a course in cell-based interaction analysis, suitable for both beginners and more experienced users.
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Instrument
Measure interactions in real time on live cells with the LigandTracer instrument. The intuitive control software lets you set up a run in no time. A large number of applications are available.
icon circle software
TraceDrawer
The software transfers relevant information from your run and lets you characterize the interaction with a few button-clicks. Multiple tools and models are available for a more thorough analysis.
icon circle courses
Training
Use the interactive self-learning software to quickly get started, or attend a course in cell-based interaction analysis, suitable for both beginners and more experienced users.

How it all started

From a tricky molecule to a successful business

It all started with a PhD student at Uppsala University, who struggled with understanding why a molecule that did bind in biophysical assays never showed any binding to target cells in her assays. This led to a conflict between biophysicists and cell biologists.

Another PhD student in the same group, Karl Andersson, realized that he had to investigate the cell-based binding in more detail. Karl knew the value of studying interactions in real-time from his decade-long experience in industry developing SPR instruments. He took the principles of real-time interaction analysis and adapted it to cells and so LigandTracer was born. The semi-automatic instrument produced data at a rate that was not possible with his manual methods and did not require him to work in the middle of the night. And the molecule then? It did indeed bind, just as he had expected, but it also released at a high rate and was almost completely gone every time he had finished the washes needed for detection with his manual method.

Karl Andersson continued working on the LigandTracer instrument and created a business focused on interaction analysis with live cells, Ridgeview Instruments. He gathered people that were just as inventive as him and just as eager to develop novel tools for scientific research. Tools that not only facilitate the work, but also provide completely new insights.

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Measure

Detect binding in live cells

LigandTracer monitors the interaction as it occurs and presents real-time binding curves containing information about the affinity, kinetics and binding mechanism. The models vary in which type of label they can detect.

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Evaluate

Understand the biology with our evaluation tools

Quantify interaction constants, compare results and prepare publishable graphs with TraceDrawer. For analysis of complex interactions the plug-in tool Interaction Map is available.

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Consumables

Additional products to facilitate your work

LigandTracer does not require any specific consumables, but we do offer some additional products that may help you in your research. For example, the MultiDish 2×2 is perfect for comparative studies or if a higher throughput is needed.

icon circle measure

Measure

Detect binding in live cells

LigandTracer monitors the interaction as it occurs and presents real-time binding curves containing information about the affinity, kinetics and binding mechanism. The models vary in which type of label they can detect.

icon circle evaluate

Evaluate

Understand the biology with our evaluation tools

Quantify interaction constants, compare results and prepare publishable graphs with TraceDrawer. The plug-in tool Interaction Map sorts out complex interactions and visualize them in a comprehensive way.

icon circle consumables

Consumables

Additional products to facilitate your work

LigandTracer does not require any specific consumables, but we do offer some additional products that may help you in your research. For example, the MultiDish 2×2 is perfect for comparative studies or if a higher throughput is needed.

Why LigandTracer?

Affinity and kinetics

Real-time

Live cells

Binding mechanism

Versatile

Low maintenance

Low running costs

Why LigandTracer?

Affinity and kinetics

Live cells

Real-time

Binding mechanism

Versatile

Low running costs

Low maintenance

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Interested in our products?

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