Radiosynthesis and Preclinical Evaluation of [68Ga]Ga-NOTA-Folate for PET Imaging of
Folate Receptor β Positive Macrophages
Moisio O, Palani S, Virta J, Elo P, Liljenbäck H, Tolvanen T, Käkelä M, Miner MG, Herre EA, Marjamäki P, Örd T, Heinäniemi M, Kaikkonen-Määttä M, Zhang F, Srinivasarao M, Knuuti J, Low PS , Saraste A, Li X-G, Roivainen A.
bioRxiv preprint. doi: https://doi.org/10.1101/2020.05.18.102483.
This study is about the evaluation of folate receptor β as a target for imaging of inflammation. The uptake of increasing concentrations of 68Ga-labeled folate to CHO cells expressing folate receptor β was monitored at 37 °C with LigandTracer Yellow, followed by a retention phase. CHO-FR-β– cells were used as a negative control, to confirm specificity.