Feasibility of Imaging EpCAM Expression in Ovarian Cancer Using Radiolabeled DARPin Ec1
Vorobyeva A, Konovalova E, Xu T, Schulga A, Altai M, Garousi J, Rinne SS, Orlova A, Tolmachev V, Deyev S.
Int J Mol Sci. 2020. 21(9): 3310.
The binding the designed ankyrin repeats protein I-PIB-Ec1 (125I-labeled) to epithelial cell adhesion molecule, a potential tumor target, expressed on OVCAR-3 or SKOV-3 cells were detected in real-time at room temperature with LigandTracer Grey to observe the kinetics, investigate cell line dependency and quantify the affinity.